The authors of this article discuss the prevention of cardiovascular disease in adult recipients of kidney transplants under the following headings:
• Premature cardiovascular disease
• Nature and determinants of post-transplantation cardiovascular disease
• Cardiovascular risk factors and prevention of cardiovascular disease
o Dyslipidaemia
o Hypertension
o New-onset diabetes after transplantation
o Other cardiovascular risk factors
• Use of interventions
• Conclusions
The key messages from the article are provided below (direct from source):
• Cardiovascular disease has an atypical nature in renal transplant recipients when compared with the general and dialysis population
• Available data support the use of statins, and standard interventions, in the management of coronary disease in transplant recipients
• In the management of hypertension, there are no data to favour one agent over another, and blood-pressure targets have been adopted from the chronic kidney disease population guidelines
• New-onset diabetes is a major, potentially modifiable risk factor for cardiovascular disease in transplant recipients
• Minimisation or avoidance of corticosteroids or calcineurin inhibitors can reduce lipid concentrations, blood pressure, and risk of diabetes, but has a restricted role in the management of cardiovascular disease after transplantation