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Review: Prevention of cardiovascular disease in adult recipients of kidney transplants

Reference: Lancet 2011; 378: 1419–27

Source: Lancet

Date published: 14/10/2011 17:14

Summary
by: Devika Sennik

The authors of this article discuss the prevention of cardiovascular disease in adult recipients of kidney transplants under the following headings:

 

• Premature cardiovascular disease

• Nature and determinants of post-transplantation cardiovascular disease

• Cardiovascular risk factors and prevention of cardiovascular disease

          o Dyslipidaemia

          o Hypertension

          o New-onset diabetes after transplantation

          o Other cardiovascular risk factors

• Use of interventions

• Conclusions

 

The key messages from the article are provided below (direct from source):

 

• Cardiovascular disease has an atypical nature in renal transplant recipients when compared with the general and dialysis population

• Available data support the use of statins, and standard interventions, in the management of coronary disease in transplant recipients

• In the management of hypertension, there are no data to favour one agent over another, and blood-pressure targets have been adopted from the chronic kidney disease population guidelines

• New-onset diabetes is a major, potentially modifiable risk factor for cardiovascular disease in transplant recipients

• Minimisation or avoidance of corticosteroids or calcineurin inhibitors can reduce lipid concentrations, blood pressure, and risk of diabetes, but has a restricted role in the management of cardiovascular disease after transplantation

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