The Archives of Neurology have featured a review on the management of patients with leptomeningeal metastases (LM). The review discusses the following:

• The biology of central nervous system metastases and LM
• Drug delivery
• Treatments, including intrathecal treatments, systemic treatments (methotrexate, capecitabine, temozolomide), hormonal therapies, and experimental treatments (pemetrexed, bevacizumab, gefitinib)
• Early treatment/prevention opportunities