This update has been prepared by the European Medicines Agency to provide a summary of the adverse drug reactions reported after the use of centrally authorised pandemic vaccines (Celvapan®, Focetria® and Pandemrix®) and Tamiflu®. It also provides information on the evolution of the H1N1 pandemic, an estimate of how many doses of vaccines and antivirals have been distributed or administered in Europe, and other available information on the benefits and risks of the vaccines and antivirals.