This case report discusses a 69-year old woman who suffered from acute pancreatitis as a result of the combination of lisinopril and olanzapine.

She had started lisinopril for hypertension three months prior to her emergency admission, and had been taking olanzapine regularly for bipolar disorder.  As other common causes were ruled out, it was concluded that the recent combination of lisinopril and olanzapine was the likely cause of the pancreatitis. Food and liquids were withheld, and all oral medicines were stopped at hospital admission. Her pain resolved completely after two days, and all of her medicines except lisinopril and olanzapine were restarted at discharge. 

Olanzapine was temporarily restarted by her primary care physician, as she had no systemic complaints during a follow-up visit; it was however discontinued a month later by her psychiatrist due to concern about recurrent pancreatitis.  Valsartan was prescribed for control of blood pressure weeks after her discharge. A follow-up CT scan of the abdomen a month later found no residual pancreatic abnormalities.