The Journal of Pain has featured the American Pain Society and the American Academy of Pain Medicine clinical guidelines for the use of chronic opioid therapy in chronic non-cancer pain. The recommendations presented in this document provide guidance on patient selection and risk stratification, informed consent and opioid management plans, initiation and titration of chronic opioid therapy, use of methadone, monitoring of patients on chronic opioid therapy, dose escalations, high-dose opioid therapy, opioid rotation, and indications for discontinuation of therapy, prevention and management of opioid-related adverse effects, driving and work safety, identifying a medical home and when to obtain consultation, management of breakthrough pain, chronic opioid therapy in pregnancy, and opioid-related polices.