This Q&A is the third in a series of seven Q&As (links to these shown below) on the use of metformin in women with polycystic ovary syndrome (PCOS). Please refer to the Q&A ‘Can metformin benefit women with polycystic ovary syndrome?’ for general background information about the condition PCOS and prescribing advice for metformin.

Rates of miscarriage during the first trimester have been reported to be three times higher in women with PCOS than in those without the syndrome.

Results of studies looking at the effect of metformin on first trimester abortion rates in women with PCOS are conflicting and inconclusive. Further large studies are required in this area.

It should be noted that metformin is licensed only for the treatment of type 2 diabetes. Therefore the prescriber takes full responsibility when prescribing metformin for PCOS.

What effect does metformin have on anovulation, pregnancy and live birth rates in women with polycystic ovary syndrome?

What effect does metformin have on hirsutism/acne?

What effect does metformin have on insulin resistance or the development of diabetes in women with polycystic ovary syndrome?

What effect does metformin have on obesity and the cardiovascular problems seen in women with polycystic ovary syndrome?

How effective is metformin compared to the oral contraceptive pill and (thiazolidinediones) glitazones in women with polycystic ovary syndrome?