Glucosamine – what are the adverse effects?

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Publisher: North West Medicines Information Centre

Keywords: Glucosamine; Adverse Effects;

Date published: 01/08/2010 17:23

Review date: 31/08/2012 17:00

Summary

by: Simone Henderson

Glucosamine supplements are widely used for the relief of pain and symptoms associated with osteoarthritis. They appear to be well tolerated, with a reported frequency of adverse effects similar to that with placebo.
Mild gastrointestinal disturbance is the most common adverse effect. Other adverse effects include headache, drowsiness, insomnia and skin reactions.
Although glucosamine should not precipitate allergic reactions in patients sensitive to shellfish, as the non-synthetic preparations are derived from the shell and not the flesh of shellfish, some sources recommend cautious use or avoidance of these products in patients at risk.
Glucosamine does not appear to adversely affect plasma blood glucose in patients without diabetes. However, data relating to its effects in patients with diabetes are lacking. It may be wise for patients with diabetes to monitor their blood glucose levels more closely if they start to take glucosamine, increase their dose or change the product taken.
Glucosamine should be used with caution in patients with renal impairment or those taking nephrotoxic medication.

About this library entry

Category: Adverse Drug Reactions | Complementary Medicine

NeLM area: Evidence > Medicines Q & A