Correction: Dextromethorphan/quinidine (Nuedexta) for pseudobulbar affect

Reference: Medical Letter on Drugs and Therapeutics 11 Jul 2011;53(1368):56

Source: Medical Letter on Drugs and Therapeutics

Keywords: Multiple Sclerosis; Dextromethorphan; Quinidine; Amyotrophic Lateral Sclerosis;

Date published: 18/07/2011 09:50

Summary
by: Paula King

Correction to a previous article (Med Lett Drugs Ther 13 Jun 2011;53(1366):46-47), which said that the FDA has approved Nuedexta for treatment of pseudobulbar affect in patients with amyotrophic lateral sclerosis (ALS) or multiple sclerosis (MS).  That is not quite correct.  The package insert says that the drug is indicated for the treatment of pseudobulbar affect and then goes on to say, in the next two sentences, that studies to support the effectiveness of Nuedexta were performed in patients with underlying ALS or MS, and that the drug has not been shown to be safe or effective in other types of emotional lability.  Also, the second sentence in the Drug Interactions paragraph should have said: "Other drugs that prolong the QT interval, inhibit CYP3A4, or are metabolized by CYP2D6 and prolong the QT interval, should be used with caution, if at all."

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Category: General Advice

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