The July edition of the MHRAs Drug Safety Update has featured a warning about the increased risk of accidental overdose with the use of intravenous paracetamol (Perfalgan®) especially in infants and neonates, due to confusion between the prescription of Perfalgan® being issued in mg and then administered in mL.

The following recommendations have been made for healthcare professionals:

• Vigilance is advised when prescribing and administering Perfalgan to ensure that the correct dose is given, especially in infants and neonates where there is a risk of confusion due to prescription in mg and administration in mL

• For all patients on the basis of their weight, adhere to the recommended dose as outlined in the Drug Safety Bulletin and in the product information; the dosing schedule is up to four infusions a day with a minimum of 4 hours between each administration, 6 hours for those with renal impairment

• For infants and children who weigh less than 33 kg, the 50 mL vial should be used

• In order to avoid overdose, intravenous paracetamol should not be given concomitantly with oral paracetamol, including combination products

Please see link below for details.