CRD Summary: The authors concluded that using propofol for prolonged sedation in critically ill patients appeared to be safe and may reduce duration of mechanical ventilation. It reduced the length of intensive care unit stay when compared to long acting benzodiazepines, but not when compared to midazolam. The authors' conclusions reflect the evidence presented and are likely to be reliable.

CRD Commentary: The review addressed a clear research question and was supported by adequate inclusion criteria. There were no languages restrictions, which reduced the possibility of language bias. Publication bias was assessed using a funnel plot, which showed that there was a possibility of small publication bias. Trial quality was assessed using appropriate criteria for the included study design. Adequate details of primary trials were provided and appropriate synthesis methods were used. The review process was carried out with sufficient attempts to minimise reviewer error and bias. The authors' conclusions reflect the evidence presented and are likely to be reliable.