Following an abbreviated submission, the Scottish Medicines Consortium (SMC) has accepted tipranavir 250mg soft capsules (Aptivus®) for restricted use within NHS Scotland, in combination with low dose ritonavir, for combination antiretroviral treatment of HIV-1 infection in highly pre-treated adolescents 12 years of age or older with virus resistant to multiple protease inhibitors.

The SMC has restricted use of tipranivir to patients with a tipranavir mutation score of <4 (this restriction also applies to adults).